\'An excellent book, the most objective short account I know of all the various approaches to depression.\' Anthony Storr Several years ago, Lewis Wolpert had a severe episode of depression. Despite a happy marriage and successful scientific career, he could think only of suicide. When he did recover, he became aware of the stigma attached to depression - and just how difficult it was to get reliable information. With characteristic candour and determination he set about writing this book, an acclaimed investigation into the causes and treatments of depression, which formed the basis for a BBC TV series.This paperback edition features a new introduction, in which Wolpert discusses the reaction to his book and BBC series, and recounts his own recurring struggle with depression.