Biofreeze Pain Relieving Roll On works using Cryotherapy, a process which dramatically cools the affected area to relieve pain in two ways; first it reduces the blood supply to the painful area and reduces the ability of the nerves to conduct pain stimuli. The unique Biofreeze formula contains Ilex, a herb extracted from the Holly shrub. Grown in South America and traditionally used by the Paraguay Indians, Ilex helps the spray to powerfully penetrate the affected areas. Biofreeze Pain Relieving Roll-On affords a number of unique features that can enhance the effectiveness and convenience of this applying the pain relief. The roller application allows the product to be administered without getting it on the hands. This can be most convenient for the older patient in applying product to hard to reach places or for someone in the workplace who must apply product during the workday. The roller application is also very beneficial in stimulating trigger points through treatment or with instruction to self-massage. The roller application is also a convenient and sanitary means to apply Biofreeze to a patient prior to ultrasound.