Frontline Spot On Cat Flea & Tick Preventative Treatment. Frontline Spot On Cat Flea & Tick Preventative Treatment kills fleas and ticks and controls biting lice on cats and is a quick and easy way to treat your cat. Frontline Spot On is easily applied with the pipette directly to the skin between the cats shoulder blades and kills fleas within 24 hours and ticks within 48 hours. Please ensure instructions are read and followed before application. Contains 1 pipettes.