Target your deepest wrinkles and dark spots with the Vital Perfection Wrinkle Spot Treatment. Shiseido\'s powerful 2-in-1 treatment visibly reduces wrinkles, smile lines, and dark spots at their root, using breakthrough ReNeura Technology++ and concentrated retinol. Enhance its effects with the full Vital Perfection routine. Retinol, vitamin A, improves the look of wrinkles by maintaining healthy skin turnover for youthfulness and radiance. 48 hours of moisture* helps keep skin plump and protected. Our innovation. Our research. Your results. Visibly reduced wrinkles, smile lines, and dark spots within 4 weeks.** Dermatologist-tested. * Instrumental test on 10 volunteers. ** Clinical test on 37 volunteers.