This altarpiece was commissioned in September 1455 by the Company of Priests of the Trinity in Pistoia; hence it represents the Trinity, and includes Saints Mamas, James the Great, Zeno and Jerome. When Pesellino died in July 1457, the painting was finished by Fra Filippo Lippi, and delivered in June 1460. This painting forms part of the Santa Trinità Altarpiece. The altarpiece was divided into several parts, probably in the 18th century, and has now been largely reassembled. The fragments entered the Collection at different dates.