This panel is one of the earliest paintings in the Collection. The Virgin is wearing a Byzantine crown and is seated on a lion-headed throne; she holds Christ on her lap. In the corners of the central section are the symbols of the four Evangelists. The eight smaller scenes on either side of the Virgin show episodes from the lives of saints: Saint John the Evangelist in a cauldron of boiling oil; Saint John the Evangelist resuscitating a woman called Drusiana; The Nativity with the Annunciation to the Shepherds; Saint Benedict rolling in brambles to overcome the temptation; Saint Nicholas\' warning to the pilgrims to throw deadly oil given to them by the devil into the sea; Saint Catherine beheaded and her body carried to Mount Sinai by angels; Saint Nicholas miraculously saving three innocent men from being decapitated; and Saint Margaret in prison swallowed by a dragon and escaping unhurt.