Tris-NAC Sterile Solution For Dogs And Cats Description Sterile solution. Tris-EDTA + N-Acetyl Cysteine Buffer (NAC) with high hygienic strength for dogs and cats. The Tris-EDTA (Ethylene Diammin Tetracetic Acid) has bactericidal activity on the growing bacterinon located within the biofilm ( Ciofu et al, 2017 ); in association with Tromethamine (Tris) it damages the bacterial cell walls and increases the penetration inside the bacterial membranes; it is well tolerated and not ototoxic; it works in synergy with chlorhexidine ( Guardabassi et al, 2010 ). Recently, in vitro work has shown that Tris-EDTA is a more than effective support in the treatment of chronic cases of otitis by Pseudomonas with the presence of potential biofilms combined with antibiotics ( Pye et al, 2014 ). NAC is an N-acetylated derivative of the amino acid cysteine, has a mucolytic action, therefore it destroys the production of exopolysaccharides thus weakening the EPS matrix. It has been used recently in eight clinical trials as an adjuvant treatment to destroy the mature biofilm and prevent its formation and has demonstrated an excellent safety and efficacy profile. The association of Tris-EDTA and NAC on the skin and in the ear before application of topical products such as chlorhexidine, antibiotics, synthetic antimicrobial peptides, therefore allows an increase in the permeability of the mature biofilm and, consequently, its disintegration , effectively supporting the overcoming of the problem of resistance to the classic antibacterial therapeutic approach. How to use 1. Apply pressure to the top of the vial until the capsule is completely ruptured. 2. Shake the bottle. 3. Withdraw the quantity to be used according to the instructions of the Veterinarian with the syringe inside the pack. In the ear canal: adequately spray and massage to the base of the ear. On the skin: spray until the area concerned is completely imbibed. Repeat the treatment as necessary or as directed by the veterinary surgeon. Format 120 ml bottle Code PP3310001