Neoxidina Mani Surgery Medical Presidium, registration No. 16594. Antiseptic liquid soap. Chlorhexidine gluconate is active against gram-positive, gram-negative bacteria, fungi and viruses. The activity of chlorhexidine depends on the pH, with an optimal variation of 5.50-7.00 which corresponds to the pH of the surfaces and tissues. Within the pH variation from 5.00 to 8.00, however, the antibacterial activity varies according to the microorganism and the type of tampon used. As an antiseptic for the hands, chlorhexidine with respect to the active ingredients, has the following characteristics: 1. Speed of action (within 15 seconds); 2. Immediate effect: after a single application reduces the cutaneous bacterial flora by 86%, compared to 68% of the Iodopovidone and 47% of the hexachlorophene; 3. Persistence of the effect: one of the most important qualities of chlorhexidine is its strong affinity with the skin. It is not absorbed but adsorbed on the skin for several hours while retaining its activity. 4. Efficacy of chlorhexidine + detergent. 5. Efficacy in the presence of blood. How to use o Antiseptic hand washing - Operating room in the preparation of the hands before surgery: moisten the hands with running water, pour about 4 ml of product (4 ml correspond to 1 stroke of the dispenser) on the parts to be treated, systematically strofinares the solution for about 1 minute, using the brush and the knife to clean the nails thoroughly; Rinse with running water, repeat the washing, prolonging it for 2 minutes and rinse and dry with a sterile cloth. - Lane, in the disinfection and cleaning of the hands to prevent contaminochips: moisten the hands with running water, pour about 4 ml of product (4 ml correspond to 1 stroke of the dispenser) on the palm of the hand, systematically rub the solution on the hands and wrists for approx. 1 minute, using the brush and the knife to thoroughly clean the nails and rinse with running water. o Complete cleaning of the patient before surgery: moisten part of the body to be treated, wash with the product (30 ml), rinse with water and repeat the wash. If a soap has been used for the preliminary cleaning of the skin, it is advisable, given the incompatibility of chlorhexidine with the soaps to be rinsed with tap water before applying diNeoxidine Mani. Chemical-physical characteristics Antiseptic and disinfectant solution, perfectly clear, red and pHneutral. Parameter Unit of measure Default values Appearance ------- Soluzionelimpida Density g / ml at 20 ? C 1.030 to 1.050 pH U of pH at 20 ? C 6.40 to 7.40 Clorexidinadigluconato % p / p 4.00 (3.80 -4.20) Contraindications Hypersensitivity to the components. Warnings The product is for exclusive external use. The use, especially if prolonged, of products for topical use, can give rise to hypersensitivity phenomena. In this case, interrupt the treatment for a short period. There are no limitations of use during pregnancy or lactation. Avoid the simultaneous use of other antiseptics and / or detergents. Do not exceed the recommended dose. Do not use the product for prolonged treatments. Accidental ingestion can have serious, sometimes fatal consequences. Avoid contact with eyes, middle ear, brain and meninges. Incompatibility The substances of the formulation are incompatible with anionic detergents, hydrogen peroxide, iodides, soaps and emulsifying agents. Chlorhexidine salts are incompatible with borates, bicarbonates, carbonates, chlorides, citrates, nitrates, phosphates and exfolates as they form little soluble salts. Chlorhexidine salts are inactivated dalsughero. Validity period 3 years packaging. If the package is opened and closed correctly at the end of each operation without the residual content being contaminated by substances and / or external agents or sub-refluxes, the preparation maintains its chemical and hemicrobiological characteristics for 60 days. storage Keep the container tightly closed, away from light and heat. Components per 100 ml of solution Active principle Chlorhexidine gluconate 4,000 g Excipients Dietanolammidedi coconut alkylpolyglucoside Polysorbate 20 PEG 150 Isopropyl alcohol Perfume Dye E 124 Purified water qs a 5,000 g 4,000 g 15,000 g 1,000 g 1,000 g 0,100g 0.005 g 100,000 g Format 30 ml heat-sealed bag, 500 and 1000 ml bottles with screw cap and 5000 ml tank cap seal with screw cap and ring seal. Code PF06710 / PF06711 / PF06714 / PF06781