Melacol Dietary supplement Melacol is a food supplement based on the polyphenolic extract of Mela annurca bell PGI (Annurcomplex(R)) and dry olive extract that promotes lipid metabolism. A retrospective observational study conducted at the Department of Surgery of the University of Modena on patients with mild and moderate hypercholesterolemia treated with Melacol showed a reduction in total cholesterol (TC) and LDL and a reduction in risk indices cardiovascular. No adverse effects have been reported throughout the duration of treatment. The benefit on lipid metabolism was determined by the combination of the two extracts by the regulation of cellular oxidative stress and the uptake of cholesterol molecules. Properties of Melacol components AnnurComplex(R): nutraceutical product based on concentrated polyphenolic extract of apple Annurcacampana IGP useful for the maintenance of normal levels of cholesterol in the blood. Olive extract dry titrated to 20% oleuropein: molecule with marked anti-radical activity against oxidized LDL cholesterol, much more marked than other antioxidant molecules, including vitamin E. Oleuropein also has the claim to be a regulator of plasma concentrations of CT, LDL cholesterol and HDL cholesterol.