MIOVEN 700 Dietary supplement of diosmin, sweet orange (hesperidin), butcher's broom. MIOVEN 700fornisce relevant information required for the maintenance of physiological venous circulation (functionality of the hemorrhoidal plexus) and for the physiological funzionalitadel microcirculation (heavy legs). Diosmin It exerts a dual action on the vessels of capacitance: a level of veins and venules, increased parietal tone and exert anti-venous stasis, while in the microcirculation increases capillary strength and normalizes lapermeabilita, making them less brittle. The protective effect of diosminaverso vascular damage is also expressed through the inhibition of the release deimediatori inflammation (prostaglandins, free radicals, cytokines) from partedelle polymorphonuclear cells and macrophages 1. Hesperidin It reduces excessive vascular permeability of the capillaries and increases endothelial laresistenza 2. Rusco Recommended for treatment of problems associated with insufficient venosacronica, such as pain, heaviness, leg cramps, swelling eprurito. 3 ruscogenin activates microcirculation and skin preserval'integrita through various mechanisms. The ruscogenin reduces lapermeabilita phone, thanks to its anti-elastasi.L'elastasi is an enzyme that degrades elastin, componentemaggioritario elastic fibers vein. Collagen and elastin are iprincipali extracellular matrix components. The anti-elastasidella ruscogenin allows to avoid the degradation of the components perivascular diridurre and thus the cell permeability. The ruscogenica has inoltreproprieta vasoconstrictor, via adrenergic mechanisms. 4-5 Ingredients Diosmin; sweet orange (hesperidin); rusco. How to use 2 tablets per day during attack and 1 tablet daily during dimantenimento and / or prevention. Warnings It can be taken by diabetics, from celiac dall'intollerante allattosio. Do not exceed the recommended daily dose. Keep out of the reach deibambini below 3 years of age. The supplements are not intended comesostituti for a varied diet. Format 20 tablets in blister pouch. Bibliography - 1. Smith PD. Neutrophil activation and mediatorsof inflammationin chronic venous insufficiency.J Vasc Res 1999; 36: 24-36. - 2. Manthey JA. Biological properties of flavonoidspertaining toinflammation. Microcirculation2000; 7: S29-S34. - 3. Phytotherapy. Rational use of herbal drugs, CapassoFrancesco, Grandolini Giuliano Izzo Angelo A - 4. Monograph Ruscus aculeatus (Butcher's Broom) Alternative Medicine Review Volume 6, Number 6. 2001. - 5. Pharmacological assessment of adrenergic receptor in humanvaricose veins. Miller VM et al. Int. Angiol. 19: 176-183. 2000.