How Panadol Advance Works Panadol Advance is formulated with Optizorb technology, unlike standard paracetamol tablets, has a quick release formula helping it to be absorbed faster than standard paracetamol tablets. Panadol Advance is also gentle on the stomach* *when used as directed.   When to use Panadol Advance Panadol Advance can be used for the relief of headaches, migraine, backache, toothache and muscle pain, as well as the fever aches and pains of cold and flu. The active ingredient paracetamol is a pain killer and reduces your body temperature when you have a fever. Panadol Advance Tablets contain paracetamol. Always read the label. 1. •Starts to release its medicine in as little as 5 minutes, helping it be absorbed faster than standard paracetamol tablets 2. •Gentle on the stomach when used as directed 3. •Reduces Fever 4. •Panadol Advance Tablets contain paracetamol for pain relief. Always read the label.