How Panadol Extra Advance Works The combination of ingredients in Panadol Extra Advance are clinically proven to provide effective relief for tough pain, including headache, migraine, backache, toothache, and rheumatic pain. The tablets contain two active ingredients to provide relief from the fever, aches and pains of cold and flu. Paracetamol is a painkiller and reduces temperature when you have a fever, whilst caffeine acts to further help the effectiveness of paracetamol. Panadol Extra Advance 500mg/65mg Tablets. Always read the label. 1. Clinically proven ingredients to relieve tough pain 2. Provides up to 37% more powerful pain relief than standard paracetamol 3. Fast-acting pain relief for 6 types of tough pain 4. Panadol Extra Advance 500mg/65mg Tablets. Always read the label.