Powerful day to night, this anti-wrinkle serum includes the highest potency of Perricone MD signature sciences. Formulated to visibly lift and improve skin plumpness, cushion, bounce and resiliency.Due to the unique technology of our Encapsulated Retinol, the formula may feel slightly gritty upon initial application. This is normal. As the product is massaged into the face, the encapsulation will break and the retinol will absorb easily into the skin. What It Is Powerful day & night serum formulated with Dr. Perricone’s next generation polyamine technology to deliver a visibly dramatic lifting effect, leaving the skin looking smooth & radiant. Supports the skin’s moisture barrier & visibly improves skin plumpness, strength, cushion, bounce & resiliency. What It Does Delivers a visibly dramatic lifting effect, leaving the skin looking smooth and radiant. Supports the skin’s moisture barrier and visibly improves skin plumpness, strength, cushion, bounce and resiliency. What To Expect Due to the unique technology of our Encapsulated Retinol, the formula may feel slightly gritty upon initial application. This is normal. As the product is massaged into the face, the encapsulation will break and the retinol will absorb easily into the skin.